Int J Physiol Pathophysiol Pharmacol 2011;3(1):9-20
Original Article Increased transforming growth factor-β1 modulates glutamate receptor expression in the hippocampus
James J. Bae, Yun-Yan Xiang, Alonso Martinez-Canabal, Paul W. Frankland, Burton B. Yang, Wei-Yang Lu
Molecular Brain Research Group, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Anesthesia, Department of Physiology, Institute of Medical Science, University of Toronto; Program in Neurosciences and Mental Health, Hospital for Sick Children; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Received August 9, 2010; Accepted September 12, 2010; Epub September 15, 2010; Published January 1, 2011.
Abstract: Transforming growth factor-beta 1 (TGF-β1) is an inflammation-related cytokine. Its expression in the brain increases under conditions of neurodegenerative diseases and injury. Previous studies have shown that genomic alterations of TGF-β1 expression in the brain cause neurodegenerative changes in aged mice. The present study revealed that increased production of TGF-β1 in transgenic mice resulted in gliosis at young ages. In addition, the increased TGF-β1 augmented the expression of some key subunits of α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors in the hippocampus. Treatment of cultured hippocampal neurons with TGF-β1 facilitated neurite outgrowth and enhanced glutamate-evoked currents. Together, these data suggest that increased TGF-β1 alters ionotropic glutamate receptor expression and function in the hippocampus. (IJPPP1008005).
Address all correspondence to: Wei-Yang Lu, MD, PhD Robarts Research Institute University of Western Ontario 100 Perth Drive, London ON Canada N6A 5K8. Tel: 1-519-931-5777 ext 24282 E-mail: wlu53@uwo.ca.