Int J Physiol Pathophysiol Pharmacol 2010;2(2):95-103
Review Article TRPM2, calcium and neurodegenerative diseases
Yu-Feng Xie, John F. MacDonald, Michael F. Jackson
Robarts Research Institute, Department of Physiology and Pharmacology, Department of Anatomy and Cell biology, University of Western Ontario, London, Ontario.
Received March 2, 2010, accepted March 8, 2010, available online March 15, 2010
Abstract: NMDA receptor overactivation triggers intracellular Ca2+ dysregulation, which has long been thought to be critical for initiating excitotoxic cell death cascades associated with stroke and neurodegenerative disease. The inability of NMDA receptor antagonists to afford neuroprotection in clinical stroke trials has led to a re-evaluation of excitotoxic models of cell death and has focused research efforts towards identifying additional Ca2+ influx pathways. Recent studies indicate that TRPM2, a member of the TPRM subfamily of Ca2+-permeant, non-selective cation channel, plays an important role in mediating cellular responses to a wide range of stimuli that, under certain situations, can induce cell death. These include reactive oxygen and nitrogen species, tumour necrosis factor as well as soluble oligomers of amyloid beta. However, the molecular basis of TRPM2 channel involvement in these processes is not fully understood. In this review, we summarize recent studies about the regulation of TRPM2, its interaction with calcium and the possible implications for neurodegenerative diseases. (IJPPP1003001).
Address all correspondence to: Dr. Michael F. Jackson Robarts Research Institute University of Western Ontario 100 Perth Drive London, Ontario N6A 5K8 E-mail: mjackson@robarts.ca
Dr. John F. MacDonald Robarts Research Institute University of Western Ontario 100 Perth Drive London, Ontario N6A 5K8 E-mail: jfmacdonald@robarts.ca