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Int J Physiol Pathophysiol Pharmacol 2011;3(1):xxx-xxx
Original Article
The Tangzhiqing Formula mediates the effect of antidiabetic on hepatic gene
expression
Wei Tian,Wei Wang, Torao Ishida, Toshihiro Miura, Hong Shi, Yuan-Yuan Zhang, De-Qin Zhang, Xiu-Mei Gao, Bo-Li Zhang
Department of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Department of
Clinical Nutrition Suzuka of University of Medical Science, Suzuka, Japan; Tianjin University of Traditional Chinese Medicine, Tianjin
300193, China.
Received August 4, 2010; accepted September, 2010; available online September, 2010
Abstract: Objective—The study was conducted to investigate the effect of feed Tangzhiqing(a traditional chinese prescription,
abbreviated as TZQ) on glucose and lipid metabolism in the liver of KKAy mice. Research design and methods—Eight-week-old male
KK-Ay mice(a genetically obese mouse model) were fed a standard diet for 4 weeks as the control group, and fed with TZQ in a dose of
0.7mg/kg, 0.35mg/kg, 0.175mg/kg of body weight as the high, middle and low dose groups, respectively. Results—Compared with
control mice, TZQ groups exhibited significantly lower plasma glucose and insulin levels throughout the experiment. Serum
concentrations of total cholesterol and triglyceride were significantly lower in TZQ groups. At 4 weeks, significant difference was
detected for the mRNA expression between control and TZQ groups. Briefly, G6Pase and PEPCK mRNA expressions were significantly
down-regulated accompanied with a significantly up-regulated PPARα, CPT-1, ACO, UCP-2 mRNA and a decreased tendency of
SREBP-1c mRNA expression in TZQ groups (P＜0.05). Conclusions—The results suggest that TZQ may produce effect on glucose
and lipid metabolism of KKAy mice, probably through, at least in part, due to increased expression of PPARα in liver. (IJPPP1008002).
Key words: Tangzhiqing, liver, PPARα, glucose and lipid metabolism
Full Text PDF
Address all correspondence to:
Wei Wang, MD, PhD
Department of Traditional Chinese Medicine
Tianjin University of Traditional Chinese Medicine
Tianjin 300193, China.
E-mail: mynov@126.com
Original Article
The Tangzhiqing Formula mediates the effect of antidiabetic on hepatic gene
expression
Wei Tian,Wei Wang, Torao Ishida, Toshihiro Miura, Hong Shi, Yuan-Yuan Zhang, De-Qin Zhang, Xiu-Mei Gao, Bo-Li Zhang
Department of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Department of
Clinical Nutrition Suzuka of University of Medical Science, Suzuka, Japan; Tianjin University of Traditional Chinese Medicine, Tianjin
300193, China.
Received August 4, 2010; accepted September, 2010; available online September, 2010
Abstract: Objective—The study was conducted to investigate the effect of feed Tangzhiqing(a traditional chinese prescription,
abbreviated as TZQ) on glucose and lipid metabolism in the liver of KKAy mice. Research design and methods—Eight-week-old male
KK-Ay mice(a genetically obese mouse model) were fed a standard diet for 4 weeks as the control group, and fed with TZQ in a dose of
0.7mg/kg, 0.35mg/kg, 0.175mg/kg of body weight as the high, middle and low dose groups, respectively. Results—Compared with
control mice, TZQ groups exhibited significantly lower plasma glucose and insulin levels throughout the experiment. Serum
concentrations of total cholesterol and triglyceride were significantly lower in TZQ groups. At 4 weeks, significant difference was
detected for the mRNA expression between control and TZQ groups. Briefly, G6Pase and PEPCK mRNA expressions were significantly
down-regulated accompanied with a significantly up-regulated PPARα, CPT-1, ACO, UCP-2 mRNA and a decreased tendency of
SREBP-1c mRNA expression in TZQ groups (P＜0.05). Conclusions—The results suggest that TZQ may produce effect on glucose
and lipid metabolism of KKAy mice, probably through, at least in part, due to increased expression of PPARα in liver. (IJPPP1008002).
Key words: Tangzhiqing, liver, PPARα, glucose and lipid metabolism
Full Text PDF
Address all correspondence to:
Wei Wang, MD, PhD
Department of Traditional Chinese Medicine
Tianjin University of Traditional Chinese Medicine
Tianjin 300193, China.
E-mail: mynov@126.com
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